Gonadorelin
cas 33515-09-2

 Product Description

Gonadorelin is another name for gonadotropin-releasing (GnRH). It is a synthetic decapeptide prepared using solid phase peptide synthesis. GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary.
GnRH is available as gonadorelin hydrochloride(Factrel®)and gonadorelin diacetate tetrahydrate(Cystorelin®)for injectable use. Studies have described it being used via an infusion pump system to induce ovulation in patients with hypothalamic hypogonadism. It is also used in veterinary medicine as a treatment for cattle with cystic ovarian disease.
Gonadorelin is a that is the same as gonadotropin-releasing(GnRH) that is naturally released from the hypothalamus gland.

 Function&Application

Gonadorelin is used to test how well the hypothalamus and the pituitary glands are working. It is also used to cause ovulation (release of an egg from the ovary) in women who do not have regular ovulation and menstrual periods because the hypothalamus gland does not release enough GnRH.
Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens.
The pulsatility of GnRH secretion has been seen in all vertebrates, and it is necessary to ensure a correct reproductive function. Thus a single hormone, GnRH, controls a complex process of follicular growth, ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male. Its short half life requires infusion pumps for its clinical use.

Product Applications

It is used for the treatment of reproductive diseases of cows and the reproductive management of cows, including simultaneous estrus and timing insemination procedures. It is mainly used in the clinical of cattle breeding industry in our country and the simultaneous estrus and timing insemination of dairy cows. It is mainly used for cows with static ovarian function. The ovarian volume is basically normal without developing follicles and corpus luteum. It is recommended that the dose is 200 micrograms for clinical treatment of dairy cows with static ovarian function. Chemicalbook is in estrus and timed insemination at the same time, the first injection of luteinizing hormone releasing hormone, 7 days later, 0.5 mg/head prostaglandin is injected to dissolve the newly formed corpus luteum. 48 hours later, the second injection of luteinizing hormone releasing hormone, followed by regular artificial insemination 16 to 24 hours later. It is recommended that the dosage of this product is 100 micrograms when cows are in estrus and timed insemination.

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